UGT2B7

Across TCGA pan-cancer cohorts, UGT2B7 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UGT2B7 data layer compared with 23 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher UGT2B7 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated UGT2B7 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

UCEC, MESO, and LGG are the cancer types where UGT2B7 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	1.000	0.431	.005	26	view →
MESO	OS	Median	All	0.144	0.557	.029	15	view →
LGG	OS	Median	All	0.148	0.909	<.001	12	view →
GBM	OS	Median	All	0.367	0.343	.019	4	view →
HNSC	OS	Median	IV	0.176	0.639	.040	3	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UGT2B7–UCEC (DFS)

Open the UCEC breakdown →