UGT2B7

Across TCGA patient cohorts, UGT2B7 mutation is significantly associated with the RNA expression of many other genes, with 2,727 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT2B7-associated genes across cancer lineages are RNU6-226P, ZMYND19, and RNA5SP461. Each is linked with UGT2B7 in more than 2 cancer types. Because this analysis shows association rather than direction, both UGT2B7-to-partner and partner-to-UGT2B7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-226P grouped by UGT2B7-low versus UGT2B7-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT2B7→partner) and Y-score (partner→UGT2B7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-226P →	+0.307	+3.867	.002	.002	3	3
UCEC	ZMYND19 →	+0.443	+2.032	<.001	<.001	3	3
SKCM	RNA5SP461 →	+0.052	+4.009	<.001	.004	3	3
GBM	MIR6858 →	+0.655	+4.969	<.001	.009	3	2
BRCA	MIR6072 →	+0.159	+7.473	<.001	.007	3	2
BLCA	OR4B2P →	+0.066	+8.051	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,727 associations by consensus.

RNU6-226P by UGT2B7 expression — HNSC

Explore this box plot interactively →