UGT2B7

Across TCGA patient cohorts, UGT2B7 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT2B7-associated genes across cancer lineages are Notch1, VHL, and CDK1. Each is linked with UGT2B7 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT2B7-to-partner and partner-to-UGT2B7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by UGT2B7-low versus UGT2B7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT2B7→partner) and Y-score (partner→UGT2B7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.137	+1.424	.003	.027	3	2
UCEC	VHL →	-0.768	-2.247	<.001	.001	3	2
UCEC	CDK1 →	+0.135	+1.584	.006	.034	3	2
UCEC	14-3-3_beta →	-0.083	-2.295	.012	.005	3	1
UCEC	EGFR_pY1068 →	-0.197	-2.222	.017	.010	3	1
UCEC	A-Raf_pS299 →	-0.084	-2.807	.033	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Notch1 by UGT2B7 expression — UCEC

Explore this box plot interactively →