UGT2B28

Across TCGA patient cohorts, UGT2B28 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT2B28-associated genes across cancer lineages are Cyclin-B1, PCNA, and FoxM1. Each is linked with UGT2B28 in more than 3 cancer types. Because this analysis shows association rather than direction, both UGT2B28-to-partner and partner-to-UGT2B28 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by UGT2B28-low versus UGT2B28-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT2B28→partner) and Y-score (partner→UGT2B28) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.520	+2.999	.015	.035	3	4
UCEC	PCNA →	+0.234	+3.700	.004	.001	3	3
LUAD	FoxM1 →	+0.369	+3.012	.006	.018	2	3
LUAD	TFRC →	+0.876	+3.169	.001	.019	2	3
UCEC	EGFR →	-0.136	-2.321	.026	.034	3	2
SKCM	MYH11 →	-0.675	-1.353	.012	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

Cyclin-B1 by UGT2B28 expression — UCEC

Explore this box plot interactively →