Across TCGA pan-cancer cohorts, UGT2B15 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UGT2B15 data layer compared with 19 for mass-spec protein and 1 for mass-spec protein.
The strongest signal is observed in small cell lung cancer (SCLC), where higher UGT2B15 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UGT2B15 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.
SCLC, UCEC, and BLCA are the cancer types where UGT2B15 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.