UGT2B10

Across TCGA patient cohorts, UGT2B10 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT2B10-associated genes across cancer lineages are 4E-BP1, EGFR, and 4E-BP1_pT70. Each is linked with UGT2B10 in more than 2 cancer types. Because this analysis shows association rather than direction, both UGT2B10-to-partner and partner-to-UGT2B10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by UGT2B10-low versus UGT2B10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT2B10→partner) and Y-score (partner→UGT2B10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.313	+2.029	.001	.017	3	3
SKCM	EGFR →	-0.157	-3.459	.003	.004	3	2
SKCM	4E-BP1_pT70 →	+0.139	+1.891	.019	.027	3	2
UCEC	Notch1 →	+0.182	+3.598	<.001	.001	3	2
UCEC	Rad50 →	-0.217	-2.102	.012	.016	3	2
SKCM	HER3_pY1289 →	-0.084	-2.288	.006	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

4E-BP1 by UGT2B10 expression — UCEC

Explore this box plot interactively →