UGT2A1

Across TCGA pan-cancer cohorts, UGT2A1 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated UGT2A1 data layer compared with 17 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher UGT2A1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UGT2A1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

LUSC, STAD, and DLBC are the cancer types where UGT2A1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.180	0.638	<.001	46	view →
STAD	OS	Median	All	0.003	0.667	<.001	30	view →
DLBC	DFS	Median	II,III,IV	0.065	0.829	<.001	24	view →
KIRC	OS	Median	All	0.128	0.630	.001	12	view →
LIHC	OS	Median	All	0.118	0.783	<.001	12	view →
ESCA	DFS	Median	II,III,IV	0.082	0.523	<.001	12	view →
GBM	OS	Median	All	0.030	0.416	<.001	6	view →
UCEC	DFS	Median	All	0.945	0.827	.024	4	view →
SARC	OS	Median	All	0.281	0.745	.046	3	view →
SKCM	DFS	Median	II,III,IV	0.843	0.668	.014	3	view →
COAD	DFS	Median	II,III,IV	0.470	0.749	.039	1	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

UGT2A1–LUSC (OS)

Open the LUSC breakdown →