UGT2A1

Across TCGA patient cohorts, UGT2A1 protein abundance is significantly associated with the RNA expression of many other genes, with 55 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible UGT2A1-associated genes across cancer lineages are ARHGAP22, STON2, and CILP2. Each is linked with UGT2A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT2A1-to-partner and partner-to-UGT2A1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, UGT2A1 versus ARHGAP22 in LUAD, with a Pearson correlation of 0.62.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT2A1→partner) and Y-score (partner→UGT2A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	ARHGAP22 →	+0.624	+2.545	<.001	.003	3	1
LUAD	STON2 →	-1.027	-2.422	<.001	.007	3	1
LUAD	CILP2 →	+1.051	+2.545	<.001	.003	3	1
LUAD	ZNF385A →	+0.723	+2.545	.003	.003	3	1
LUAD	ABRAXAS2 →	-0.379	-2.012	.005	.005	3	1
LUAD	LRRC15 →	+1.567	+1.752	.008	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 55 associations by consensus.

UGT2A1 vs ARHGAP22 — LUAD

Explore this scatter interactively →