UGT2A1

Across TCGA patient cohorts, UGT2A1 mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT2A1-associated genes across cancer lineages are ATM, PDK1_pS241, and XBP1. Each is linked with UGT2A1 in more than 2 cancer types. Because this analysis shows association rather than direction, both UGT2A1-to-partner and partner-to-UGT2A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by UGT2A1-low versus UGT2A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT2A1→partner) and Y-score (partner→UGT2A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.484	-1.925	<.001	.004	3	3
UCEC	PDK1_pS241 →	+0.121	+1.321	.017	.027	3	2
UCEC	XBP1 →	-0.133	-1.247	.001	.041	3	2
UCEC	Caspase-7-cleavedD198 →	+0.562	+1.785	.001	.007	3	2
UCEC	4E-BP1 →	+0.352	+2.662	<.001	<.001	3	2
UCEC	C-Raf →	+0.144	+1.378	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

ATM by UGT2A1 expression — UCEC

Explore this box plot interactively →