UGT2A1

Across TCGA cell cohorts, UGT2A1 mutation is significantly associated with the RNA expression of many other genes, with 36 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UGT2A1-associated genes across cancer lineages are TMEM239, NANOGNB, and SBK3. Each is linked with UGT2A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT2A1-to-partner and partner-to-UGT2A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM239 grouped by UGT2A1-low versus UGT2A1-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT2A1→partner) and Y-score (partner→UGT2A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	TMEM239 →	+0.016	+4.807	<.001	.006	3	1
BLOOD_Myeloma	NANOGNB →	+0.643	+4.807	.001	.006	3	1
BLOOD_Myeloma	SBK3 →	+0.020	+4.807	<.001	.006	3	1
BLOOD_Myeloma	GPR142 →	+0.060	+4.807	<.001	.006	3	1
SOFT_TISSUE	PADI6 →	+0.006	+3.169	<.001	.007	3	1
SOFT_TISSUE	SLURP2 →	+0.068	+3.247	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

TMEM239 by UGT2A1 expression — BLOOD_Myeloma

Explore this box plot interactively →