UGT1A9

Across TCGA patient cohorts, UGT1A9 mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT1A9-associated genes across cancer lineages are RAD51, TAZ, and Chk2_pT68. Each is linked with UGT1A9 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT1A9-to-partner and partner-to-UGT1A9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAD51 grouped by UGT1A9-low versus UGT1A9-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A9→partner) and Y-score (partner→UGT1A9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RAD51 →	+0.244	+3.203	.024	.008	3	1
SKCM	TAZ →	+0.176	+3.182	.016	.009	3	1
SKCM	Chk2_pT68 →	+0.197	+2.334	.006	.018	3	1
UCEC	INPP4B →	-0.434	-2.999	.014	.035	3	1
UCEC	Myosin-IIa →	+0.234	+3.007	.029	.019	3	1
UCEC	MEK1 →	+0.584	+3.169	.003	.020	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

RAD51 by UGT1A9 expression — SKCM

Explore this box plot interactively →