UGT1A8

Across TCGA patient cohorts, UGT1A8 mutation is significantly associated with the RNA expression of many other genes, with 907 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT1A8-associated genes across cancer lineages are RNA5SP536, OR5K1, and MIR7845. Each is linked with UGT1A8 in more than 2 cancer types. Because this analysis shows association rather than direction, both UGT1A8-to-partner and partner-to-UGT1A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP536 grouped by UGT1A8-low versus UGT1A8-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A8→partner) and Y-score (partner→UGT1A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNA5SP536 →	+0.506	+4.798	<.001	.006	3	3
LGG	OR5K1 →	+0.069	+5.392	<.001	.005	3	2
SKCM	MIR7845 →	+0.249	+2.601	<.001	.003	3	2
LUAD	FAM138D →	+0.042	+4.631	<.001	.008	3	2
LUAD	RNU6-991P →	+0.898	+4.787	<.001	.003	3	2
LUSC	RNU6-922P →	+0.379	+4.736	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 907 associations by consensus.

RNA5SP536 by UGT1A8 expression — LUAD

Explore this box plot interactively →