UGT1A8

Across TCGA patient cohorts, UGT1A8 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT1A8-associated genes across cancer lineages are Annexin-1, eIF4E, and ACC1. Each is linked with UGT1A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT1A8-to-partner and partner-to-UGT1A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by UGT1A8-low versus UGT1A8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A8→partner) and Y-score (partner→UGT1A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.790	+3.604	<.001	.001	3	2
UCEC	eIF4E →	+0.230	+3.584	.010	.002	3	1
UCEC	ACC1 →	+0.334	+2.222	.030	.011	3	1
UCEC	IGFBP2 →	-0.909	-3.459	<.001	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.206	-3.000	.003	.036	3	1
UCEC	JNK2 →	+0.174	+2.222	.038	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Annexin-1 by UGT1A8 expression — UCEC

Explore this box plot interactively →