UGT1A8

Across TCGA cell cohorts, UGT1A8 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UGT1A8-associated genes across cancer lineages are NOBOX, KRTAP13-4, and LCE1C. Each is linked with UGT1A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT1A8-to-partner and partner-to-UGT1A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOBOX grouped by UGT1A8-low versus UGT1A8-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A8→partner) and Y-score (partner→UGT1A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NOBOX →	+0.072	+5.539	<.001	.003	3	1
BLOOD_Leukemia	KRTAP13-4 →	+0.045	+5.539	<.001	.003	3	1
BLOOD_Leukemia	LCE1C →	+0.432	+4.922	.002	.009	3	1
BLOOD_Leukemia	SLC5A8 →	+0.182	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR10A6 →	+0.044	+5.201	<.001	.006	3	1
BLOOD_Leukemia	CFHR2 →	+0.395	+5.539	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

NOBOX by UGT1A8 expression — BLOOD_Leukemia

Explore this box plot interactively →