UGT1A7

Across TCGA patient cohorts, UGT1A7 protein abundance is significantly associated with the RNA expression of many other genes, with 4,400 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible UGT1A7-associated genes across cancer lineages are TTLL12, SYNGR1, and KLF5. Each is linked with UGT1A7 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT1A7-to-partner and partner-to-UGT1A7 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, UGT1A7 versus TTLL12 in HNSC, with a Pearson correlation of 0.28.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A7→partner) and Y-score (partner→UGT1A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	TTLL12 →	+0.791	+0.688	.001	<.001	3	2
HNSC	SYNGR1 →	+0.818	+0.701	<.001	.002	3	2
LSCC	KLF5 →	+1.228	+1.468	<.001	<.001	3	2
LSCC	CD9 →	+0.706	+1.174	.001	.002	3	2
LSCC	NECAB2 →	+1.505	+1.635	<.001	<.001	3	2
LSCC	MYH14 →	+1.210	+1.660	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,400 associations by consensus.

UGT1A7 vs TTLL12 — HNSC

Explore this scatter interactively →