UGT1A7

Across TCGA patient cohorts, UGT1A7 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT1A7-associated genes across cancer lineages are 14-3-3_beta, INPP4B, and JNK_pT183_Y185. Each is linked with UGT1A7 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT1A7-to-partner and partner-to-UGT1A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by UGT1A7-low versus UGT1A7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A7→partner) and Y-score (partner→UGT1A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.130	-3.295	.003	.009	3	1
UCEC	INPP4B →	-0.329	-3.321	.020	.009	3	1
UCEC	JNK_pT183_Y185 →	-0.155	-2.102	.034	.019	3	1
UCEC	JNK2 →	+0.241	+2.807	.005	.003	3	1
UCEC	Ku80 →	+0.222	+1.598	.031	.044	3	1
UCEC	MEK1 →	+0.517	+2.115	.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

14-3-3_beta by UGT1A7 expression — UCEC

Explore this box plot interactively →