UGT1A7

Across TCGA cell cohorts, UGT1A7 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UGT1A7-associated genes across cancer lineages are DBX1, AMELX, and KRTAP3-1. Each is linked with UGT1A7 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT1A7-to-partner and partner-to-UGT1A7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DBX1 grouped by UGT1A7-low versus UGT1A7-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A7→partner) and Y-score (partner→UGT1A7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DBX1 →	+0.129	+4.551	<.001	.004	3	1
BLOOD_Leukemia	AMELX →	+0.028	+4.539	<.001	.007	3	1
BLOOD_Leukemia	KRTAP3-1 →	+0.028	+4.539	<.001	.007	3	1
BLOOD_Leukemia	CBLN4 →	+0.004	+4.539	<.001	.007	3	1
LARGE_INTESTINE	TBC1D21 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	BPY2 →	+0.018	+4.437	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

DBX1 by UGT1A7 expression — BLOOD_Leukemia

Explore this box plot interactively →