UGT1A6

Across TCGA pan-cancer cohorts, UGT1A6 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UGT1A6 data layer compared with 22 for mass-spec protein and 8 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher UGT1A6 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated UGT1A6 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

LUAD, CCRCC, and UCEC are the cancer types where UGT1A6 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	All	0.745	0.994	<.001	31	view →
CCRCC	OS	Tertile	II,III,IV	0.989	0.691	.008	22	view →
UCEC	DFS	Median	III,IV	0.350	1.000	.006	16	view →
PDAC	OS	Tertile	III,IV	0.178	0.830	.014	8	view →
LSCC	OS	Quartile	All	0.871	1.000	.007	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UGT1A6–LUAD (DFS)

Open the LUAD breakdown →