UGT1A6

Across TCGA patient cohorts, UGT1A6 protein abundance is significantly associated with the RNA expression of many other genes, with 5,051 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible UGT1A6-associated genes across cancer lineages are NMRAL2P, AKR1C3, and GCLC. Each is linked with UGT1A6 in more than 4 cancer types. Because this analysis shows association rather than direction, both UGT1A6-to-partner and partner-to-UGT1A6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, UGT1A6 versus NMRAL2P in LSCC, with a Pearson correlation of 0.60.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A6→partner) and Y-score (partner→UGT1A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NMRAL2P →	+3.308	+1.161	<.001	<.001	3	5
LSCC	AKR1C3 →	+2.991	+1.259	<.001	<.001	3	5
LSCC	GCLC →	+1.453	+1.046	<.001	<.001	3	4
LSCC	G6PD →	+1.317	+1.324	<.001	<.001	3	4
LSCC	DNAJB3 →	+2.528	+1.473	<.001	<.001	3	4
LSCC	UGT1A2P →	+2.554	+1.470	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,051 associations by consensus.

UGT1A6 vs NMRAL2P — LSCC

Explore this scatter interactively →