UGT1A6

Across TCGA patient cohorts, UGT1A6 mutation is significantly associated with the RNA expression of many other genes, with 4,626 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT1A6-associated genes across cancer lineages are RNU6-661P, NKX2-6, and RTN3P1. Each is linked with UGT1A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT1A6-to-partner and partner-to-UGT1A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-661P grouped by UGT1A6-low versus UGT1A6-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A6→partner) and Y-score (partner→UGT1A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU6-661P →	+0.209	+5.144	<.001	.003	3	2
LUAD	NKX2-6 →	+0.433	+4.198	<.001	.003	3	2
SKCM	RTN3P1 →	+0.199	+3.546	.002	.002	3	2
SKCM	BOLA2-SMG1P6 →	+0.368	+2.453	.008	.001	3	2
SKCM	NBPF15 →	+0.559	+3.826	.001	<.001	3	2
STAD	RNU6-1072P →	+0.212	+4.343	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,626 associations by consensus.

RNU6-661P by UGT1A6 expression — CESC

Explore this box plot interactively →