UGT1A6

Across TCGA patient cohorts, UGT1A6 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT1A6-associated genes across cancer lineages are Notch1, ASNS, and ATM. Each is linked with UGT1A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT1A6-to-partner and partner-to-UGT1A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by UGT1A6-low versus UGT1A6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A6→partner) and Y-score (partner→UGT1A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.183	+2.000	<.001	.010	3	2
UCEC	ASNS →	+0.449	+1.584	.001	.036	3	2
UCEC	ATM →	-0.596	-2.115	<.001	.017	3	2
UCEC	4E-BP1 →	+0.322	+1.584	.002	.036	3	2
UCEC	eIF4E →	+0.182	+2.000	.027	.010	3	1
UCEC	ERK2 →	+0.208	+2.000	.005	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Notch1 by UGT1A6 expression — UCEC

Explore this box plot interactively →