UGT1A6

Across TCGA cell cohorts, UGT1A6 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible UGT1A6-associated genes across cancer lineages are AGXT2, USP29, and TAAR8. Each is linked with UGT1A6 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT1A6-to-partner and partner-to-UGT1A6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AGXT2 grouped by UGT1A6-low versus UGT1A6-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A6→partner) and Y-score (partner→UGT1A6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	AGXT2 →	+0.012	+4.371	.006	.005	3	1
LUNG_NSCLC_LUAD	USP29 →	+0.012	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	TAAR8 →	+0.017	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	FBXO40 →	+0.006	+5.189	<.001	<.001	3	1
LUNG_NSCLC_LUAD	UMOD →	+0.005	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	BEND2 →	+0.018	+4.544	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

AGXT2 by UGT1A6 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →