UGT1A4

Across TCGA patient cohorts, UGT1A4 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,001 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible UGT1A4-associated proteins across cancer lineages are AKR1C3, UGT1A6, and AKR1C1. Each is linked with UGT1A4 in more than 4 cancer types. Because this analysis shows association rather than direction, both UGT1A4-to-partner and partner-to-UGT1A4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, UGT1A4 versus AKR1C3 in LSCC, with a Pearson correlation of 0.62.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A4→partner) and Y-score (partner→UGT1A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1C3 →	+1.759	+2.073	<.001	<.001	3	5
LSCC	UGT1A6 →	+1.405	+2.207	<.001	<.001	3	4
LSCC	AKR1C1 →	+2.205	+2.283	<.001	<.001	3	4
LSCC	AKR1C2 →	+1.894	+2.057	<.001	<.001	3	4
LSCC	AKR1C3_S129 →	+1.806	+1.710	<.001	<.001	3	4
LSCC	ME1 →	+1.044	+2.246	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,001 associations by consensus.

UGT1A4 vs AKR1C3 — LSCC

Explore this scatter interactively →