UGT1A4

Across TCGA cell cohorts, UGT1A4 mutation is significantly associated with the RNA expression of many other genes, with 11 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UGT1A4-associated genes across cancer lineages are CPLX4, IL26, and IAPP. Each is linked with UGT1A4 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT1A4-to-partner and partner-to-UGT1A4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CPLX4 grouped by UGT1A4-low versus UGT1A4-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A4→partner) and Y-score (partner→UGT1A4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CPLX4 →	+0.046	+4.392	<.001	.004	3	2
LARGE_INTESTINE	IL26 →	+0.542	+3.793	<.001	.007	3	1
LARGE_INTESTINE	IAPP →	+0.593	+3.906	<.001	.005	3	1
LARGE_INTESTINE	BPIFA2 →	+0.108	+3.793	<.001	.007	3	1
LARGE_INTESTINE	GALP →	+0.016	+4.437	<.001	.004	3	1
LARGE_INTESTINE	TRPC5OS →	+0.028	+3.854	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

CPLX4 by UGT1A4 expression — LARGE_INTESTINE

Explore this box plot interactively →