UGT1A3

Across TCGA pan-cancer cohorts, UGT1A3 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated UGT1A3 data layer compared with 22 for mass-spec protein.

The strongest signal is observed in thymoma (THYM), where higher UGT1A3 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated UGT1A3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

THYM, UCEC, and LUAD are the cancer types where UGT1A3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
THYM	OS	Median	III,IV	0.103	0.944	<.001	42	view →
UCEC	DFS	Median	All	0.934	0.622	.010	34	view →
LUAD	DFS	Median	III,IV	0.221	0.691	.001	25	view →
OV	OS	Median	III,IV	0.007	0.837	<.001	24	view →
BRCA	OS	Median	III,IV	0.287	0.833	.002	12	view →
SCLC	OS	Median	All	0.301	0.711	.018	12	view →
COAD	OS	Median	III,IV	0.133	0.780	<.001	6	view →
BLCA	OS	Median	II,III,IV	1.000	0.412	.022	6	view →
SKCM	OS	Median	All	0.547	0.323	.027	5	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

UGT1A3–THYM (OS)

Open the THYM breakdown →