UGT1A3

Across TCGA patient cohorts, UGT1A3 RNA expression is significantly associated with the protein abundance of many other proteins, with 10,773 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible UGT1A3-associated proteins across cancer lineages are AKR1C3, UGT1A6, and AKR1C2. Each is linked with UGT1A3 in more than 4 cancer types. Because this analysis shows association rather than direction, both UGT1A3-to-partner and partner-to-UGT1A3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, UGT1A3 versus AKR1C3 in LSCC, with a Pearson correlation of 0.60.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A3→partner) and Y-score (partner→UGT1A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1C3 →	+1.686	+1.627	<.001	<.001	3	5
LUAD	UGT1A6 →	+1.388	+0.670	<.001	<.001	3	4
LSCC	AKR1C2 →	+1.888	+1.582	<.001	<.001	3	4
PDAC	AKR1C3_S129 →	+1.684	+0.684	<.001	<.001	3	4
HNSC	UBA2 →	+0.313	+1.041	<.001	<.001	3	3
PDAC	VAV3 →	-0.363	-0.420	<.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,773 associations by consensus.

UGT1A3 vs AKR1C3 — LSCC

Explore this scatter interactively →