UGT1A3

Across TCGA patient cohorts, UGT1A3 mutation is significantly associated with the RNA expression of many other genes, with 1,998 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT1A3-associated genes across cancer lineages are CENPX, GSKIP, and GPIHBP1. Each is linked with UGT1A3 in more than 3 cancer types. Because this analysis shows association rather than direction, both UGT1A3-to-partner and partner-to-UGT1A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPX grouped by UGT1A3-low versus UGT1A3-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A3→partner) and Y-score (partner→UGT1A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CENPX →	+0.308	+1.899	.004	.003	3	4
UCEC	GSKIP →	+0.351	+1.934	.003	.002	3	4
UCEC	GPIHBP1 →	-0.348	-1.830	.001	<.001	3	3
SKCM	SAC3D1 →	+0.324	+2.273	.005	<.001	3	3
SKCM	ZNF511 →	+0.360	+2.623	<.001	<.001	3	3
UCEC	CLEC1A →	-0.249	-2.226	.004	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,998 associations by consensus.

CENPX by UGT1A3 expression — SKCM

Explore this box plot interactively →