UGT1A3

Across TCGA patient cohorts, UGT1A3 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT1A3-associated genes across cancer lineages are Caspase-7-cleavedD198, Notch1, and eEF2. Each is linked with UGT1A3 in more than 3 cancer types. Because this analysis shows association rather than direction, both UGT1A3-to-partner and partner-to-UGT1A3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by UGT1A3-low versus UGT1A3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A3→partner) and Y-score (partner→UGT1A3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.381	+2.700	.031	.005	3	4
UCEC	Notch1 →	+0.121	+1.515	.003	.015	3	3
STAD	eEF2 →	+0.402	+3.000	.010	.036	3	2
STAD	beta-Catenin →	+0.760	+3.000	.043	.036	3	2
UCEC	ERK2 →	+0.160	+1.874	.005	.002	3	2
UCEC	Mre11 →	-0.052	-1.184	.041	.022	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Caspase-7-cleavedD198 by UGT1A3 expression — UCEC

Explore this box plot interactively →