UGT1A10

Across TCGA patient cohorts, UGT1A10 mutation is significantly associated with the total protein of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT1A10-associated genes across cancer lineages are Notch1, Caspase-8, and INPP4B. Each is linked with UGT1A10 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT1A10-to-partner and partner-to-UGT1A10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by UGT1A10-low versus UGT1A10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A10→partner) and Y-score (partner→UGT1A10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.197	+3.472	<.001	.002	3	2
UCEC	Caspase-8 →	-0.254	-3.558	.014	.002	3	2
UCEC	INPP4B →	-0.277	-3.169	.038	.018	3	1
UCEC	p62 Lck ligand →	+0.267	+2.321	.046	.006	3	1
UCEC	Rab25 →	-0.285	-2.999	.037	.035	3	1
UCEC	Rad50 →	-0.206	-2.321	.039	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Notch1 by UGT1A10 expression — UCEC

Explore this box plot interactively →