UGT1A1

Across TCGA patient cohorts, UGT1A1 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,807 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible UGT1A1-associated proteins across cancer lineages are AKR1C3, AKR1C2, and PPP1R18. Each is linked with UGT1A1 in more than 5 cancer types. Because this analysis shows association rather than direction, both UGT1A1-to-partner and partner-to-UGT1A1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, UGT1A1 versus AKR1C3 in LSCC, with a Pearson correlation of 0.63.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A1→partner) and Y-score (partner→UGT1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	AKR1C3 →	+1.794	+1.947	<.001	<.001	3	6
LSCC	AKR1C2 →	+1.924	+1.915	<.001	<.001	3	5
LSCC	PPP1R18 →	-0.325	-1.220	<.001	<.001	3	4
LSCC	OPA1 →	+0.355	+0.991	<.001	<.001	3	4
LSCC	AKR1C1 →	+2.198	+2.117	<.001	<.001	3	4
LSCC	HTATIP2 →	+0.511	+1.456	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,807 associations by consensus.

UGT1A1 vs AKR1C3 — LSCC

Explore this scatter interactively →