UGT1A1

Across TCGA patient cohorts, UGT1A1 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGT1A1-associated genes across cancer lineages are ERK2, Notch1, and PTEN. Each is linked with UGT1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT1A1-to-partner and partner-to-UGT1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by UGT1A1-low versus UGT1A1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A1→partner) and Y-score (partner→UGT1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.206	+2.584	.021	.011	3	1
UCEC	Notch1 →	+0.179	+3.179	.006	.010	3	1
UCEC	PTEN →	-0.423	-3.000	.022	.036	3	1
UCEC	ASNS →	+0.664	+3.169	<.001	.018	3	1
UCEC	ATM →	-0.606	-2.321	.004	.034	3	1
UCEC	Cyclin-B1 →	+0.656	+2.584	.012	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ERK2 by UGT1A1 expression — UCEC

Explore this box plot interactively →