UGT1A1

Across TCGA cell cohorts, UGT1A1 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UGT1A1-associated genes across cancer lineages are LCN1, COX6A2, and DEFA4. Each is linked with UGT1A1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGT1A1-to-partner and partner-to-UGT1A1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LCN1 grouped by UGT1A1-low versus UGT1A1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGT1A1→partner) and Y-score (partner→UGT1A1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	LCN1 →	+0.529	+5.029	<.001	.006	3	1
LARGE_INTESTINE	COX6A2 →	+0.068	+4.022	<.001	.006	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.010	+4.022	<.001	.006	3	1
LARGE_INTESTINE	GSG1L2 →	+0.013	+4.022	<.001	.006	3	1
LARGE_INTESTINE	CT45A3 →	+0.258	+3.994	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

LCN1 by UGT1A1 expression — LUNG_SCLC

Explore this box plot interactively →