UGP2

Across TCGA pan-cancer cohorts, UGP2 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated UGP2 data layer compared with 27 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher UGP2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated UGP2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and OV show a favorable association.

HNSC, GBM, and OV are the cancer types where UGP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	III,IV	0.920	0.658	.001	29	view →
GBM	DFS	Quartile	All	0.225	0.475	.013	11	view →
OV	DFS	Median	All	0.923	0.670	.036	8	view →
CCRCC	DFS	Tertile	All	0.640	0.858	.010	7	view →
LUAD	OS	Tertile	All	0.662	0.879	.031	5	view →
UCEC	DFS	Tertile	All	0.951	0.804	.047	4	view →
LSCC	OS	Tertile	All	0.959	0.815	.027	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

UGP2–HNSC (DFS)

Open the HNSC breakdown →