UGGT2

Across TCGA patient cohorts, UGGT2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UGGT2-associated genes across cancer lineages are Caspase-7-cleavedD198, Akt_pT308, and Annexin-1. Each is linked with UGGT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both UGGT2-to-partner and partner-to-UGGT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by UGGT2-low versus UGGT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGGT2→partner) and Y-score (partner→UGGT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.454	+2.019	.018	.005	3	3
LUSC	Akt_pT308 →	+0.525	+2.179	.010	.035	3	2
UCEC	Annexin-1 →	+0.612	+2.019	<.001	.005	3	2
COAD	Tuberin →	+0.401	+3.178	.011	.010	3	2
COAD	Cyclin-B1 →	+0.598	+3.000	.026	.035	3	2
UCEC	PCNA →	+0.198	+2.321	.004	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Caspase-7-cleavedD198 by UGGT2 expression — UCEC

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