UGGT2

Across TCGA cell cohorts, UGGT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,309 significant associations in total. BONE shows the largest number of these associations.

The most reproducible UGGT2-associated GO terms across cancer lineages are Endoplasmic reticulum mannose trimming, Ribosomal protein import into nucleus, and Negative regulation of hematopoietic stem cell differentiation. Each is linked with UGGT2 in more than 14 cancer types. Because this analysis shows association rather than direction, both UGGT2-to-partner and partner-to-UGGT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endoplasmic reticulum mannose trimming grouped by UGGT2-low versus UGGT2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UGGT2→partner) and Y-score (partner→UGGT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Endoplasmic reticulum mannose trimming →	+0.120	+1.545	<.001	<.001	3	15
BREAST	Ribosomal protein import into nucleus →	+0.109	+0.875	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Negative regulation of hematopoietic stem cell differentiation →	+0.147	+0.887	.001	.008	3	13
BONE	Positive regulation of translational initiation in response to stress →	+0.274	+2.437	<.001	<.001	3	13
BONE	Nucleotide-sugar metabolic process →	+0.084	+1.592	.005	.002	3	12
BREAST	UDP-alpha-D-glucose metabolic process →	+0.105	+1.154	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,309 associations by consensus.

Endoplasmic reticulum mannose trimming by UGGT2 expression — BONE

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