UGGT2

Across TCGA cell cohorts, UGGT2 mutation is significantly associated with the RNA expression of many other genes, with 41 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible UGGT2-associated genes across cancer lineages are MBD3L3, ZNF831, and BHLHE23. Each is linked with UGGT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UGGT2-to-partner and partner-to-UGGT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L3 grouped by UGGT2-low versus UGGT2-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UGGT2→partner) and Y-score (partner→UGGT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MBD3L3 →	+0.020	+4.643	<.001	.008	3	2
LARGE_INTESTINE	ZNF831 →	+0.010	+2.688	<.001	.008	3	2
LUNG_NSCLC_LUSC	BHLHE23 →	+0.020	+4.643	<.001	.008	3	1
LUNG_NSCLC_LUSC	CCL13 →	+0.040	+4.643	<.001	.008	3	1
SKIN	MSGN1 →	+0.038	+3.700	<.001	.009	3	1
SKIN	HMHB1 →	+0.032	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

MBD3L3 by UGGT2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →