UGCG

Across TCGA pan-cancer cohorts, UGCG mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of UGCG’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where UGCG mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types UGCG is over-expressed in tumor, although a few such as LSCC and LUAD show the opposite, repressed pattern.

COAD, LSCC, and LUAD are the cancer types where UGCG tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UGCG mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+1.069	<.001	10	view →
LSCC	Male	All	−0.328	<.001	7	view →
LUAD	All	All	−0.194	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

UGCG–COAD

Open the COAD breakdown →