UFSP2

Across TCGA pan-cancer cohorts, UFSP2 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated UFSP2 data layer compared with 24 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher UFSP2 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated UFSP2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC and UCEC show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where UFSP2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.659	0.964	.001	33	view →
CCRCC	OS	Quartile	III,IV	0.830	0.368	.003	25	view →
PDAC	DFS	Median	IV	0.250	0.934	.024	6	view →
UCEC	OS	Quartile	All	1.000	0.838	.020	4	view →
GBM	DFS	Quartile	All	0.690	0.875	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

UFSP2–LSCC (OS)

Open the LSCC breakdown →