UFSP2

Across TCGA patient cohorts, UFSP2 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UFSP2-associated genes across cancer lineages are MEK1, IGFBP2, and Ku80. Each is linked with UFSP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UFSP2-to-partner and partner-to-UFSP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by UFSP2-low versus UFSP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UFSP2→partner) and Y-score (partner→UFSP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.260	+1.765	.023	.013	3	2
UCEC	IGFBP2 →	-0.729	-1.999	<.001	.008	3	1
UCEC	Ku80 →	+0.209	+1.366	.004	.010	3	1
UCEC	MSH2 →	-0.211	-1.651	.003	.019	3	1
UCEC	Myosin-IIa_pS1943 →	+0.132	+1.150	.041	.028	3	1
UCEC	Notch1 →	+0.122	+1.598	.005	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

MEK1 by UFSP2 expression — UCEC

Explore this box plot interactively →