UFM1

Across TCGA pan-cancer cohorts, UFM1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UFM1 data layer compared with 27 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher UFM1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated UFM1 expression acts as an unfavorable survival marker, although some lineages such as COAD and PDAC show a favorable association.

LSCC, COAD, and PDAC are the cancer types where UFM1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.551	0.869	<.001	53	view →
COAD	DFS	Median	All	1.000	0.887	.022	30	view →
PDAC	DFS	Tertile	All	0.520	0.321	.005	19	view →
LUAD	OS	Quartile	II,III,IV	0.432	0.863	.009	16	view →
HNSC	OS	Median	II,III,IV	0.953	1.000	.019	8	view →
GBM	OS	Quartile	All	0.570	0.915	.013	5	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UFM1–LSCC (DFS)

Open the LSCC breakdown →