UFM1

Across TCGA patient cohorts, UFM1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UFM1-associated genes across cancer lineages are RNU6-1318P, TRAJ56, and TRAJ21. Each is linked with UFM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UFM1-to-partner and partner-to-UFM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1318P grouped by UFM1-low versus UFM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UFM1→partner) and Y-score (partner→UFM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1318P →	+0.584	+3.943	<.001	.002	3	1
UCEC	TRAJ56 →	+0.483	+3.474	.002	.006	3	1
UCEC	TRAJ21 →	+0.945	+3.766	<.001	.001	3	1
UCEC	RNU2-63P →	+0.730	+3.958	.003	.002	3	1
UCEC	FDX1P2 →	+0.198	+3.386	.001	.008	3	1
UCEC	RNA5SP288 →	+0.560	+3.474	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

RNU6-1318P by UFM1 expression — UCEC

Explore this box plot interactively →