UFM1

Across TCGA cell cohorts, UFM1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,233 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible UFM1-associated GO terms across cancer lineages are Negative regulation of hematopoietic stem cell differentiation, Retrograde transport, vesicle recycling within Golgi, and Protein polyufmylation. Each is linked with UFM1 in more than 17 cancer types. Because this analysis shows association rather than direction, both UFM1-to-partner and partner-to-UFM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of hematopoietic stem cell differentiation grouped by UFM1-low versus UFM1-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (UFM1→partner) and Y-score (partner→UFM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of hematopoietic stem cell differentiation →	+0.173	+0.943	<.001	.001	3	18
PANCREAS	Retrograde transport, vesicle recycling within Golgi →	+0.148	+1.073	<.001	<.001	3	17
BLOOD_Myeloma	Protein polyufmylation →	+0.145	+0.867	.003	.008	3	15
BLOOD_Myeloma	Protein K69-linked ufmylation →	+0.145	+0.867	.003	.008	3	15
BLOOD_Myeloma	Protein ufmylation →	+0.146	+1.044	<.001	<.001	3	15
OESOPHAGUS	Intra-Golgi vesicle-mediated transport →	+0.089	+0.767	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,233 associations by consensus.

Negative regulation of hematopoietic stem cell differentiation by UFM1 expression — LUNG_SCLC

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