UFL1

Across TCGA pan-cancer cohorts, UFL1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated UFL1 data layer compared with 22 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher UFL1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated UFL1 expression acts as an unfavorable survival marker, although some lineages such as COAD and LSCC show a favorable association.

COAD, LSCC, and PDAC are the cancer types where UFL1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	1.000	0.827	.018	60	view →
LSCC	DFS	Median	All	0.894	0.518	.032	3	view →
PDAC	DFS	Tertile	IV	0.217	0.550	.024	3	view →
CCRCC	OS	Quartile	II,III,IV	1.000	0.660	.017	2	view →
GBM	OS	Quartile	All	0.410	0.626	.047	2	view →
HNSC	OS	Median	IV	0.640	0.810	.046	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

UFL1–COAD (DFS)

Open the COAD breakdown →