UFL1

Across TCGA pan-cancer cohorts, UFL1 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of UFL1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where UFL1 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types UFL1 is over-expressed in tumor, although a few such as PDAC and CCRCC show the opposite, repressed pattern.

LUAD, PDAC, and COAD are the cancer types where UFL1 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UFL1 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	+0.181	<.001	8	view →
PDAC	Female	All	−0.738	<.001	6	view →
COAD	All	All	+0.060	.004	5	view →
LSCC	Male	All	+0.119	<.001	4	view →
OV	All	All	+0.292	.006	2	view →
CCRCC	All	All	−0.072	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

UFL1–LUAD

Open the LUAD breakdown →