UFL1

Across TCGA cell cohorts, UFL1 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UFL1-associated genes across cancer lineages are RBMY1A1, NPHS2, and ARHGAP36. Each is linked with UFL1 in more than 1 cancer types. Because this analysis shows association rather than direction, both UFL1-to-partner and partner-to-UFL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RBMY1A1 grouped by UFL1-low versus UFL1-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UFL1→partner) and Y-score (partner→UFL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RBMY1A1 →	+0.086	+4.222	<.001	.006	3	1
UPPER_AERODIGESTIVE_TRACT	NPHS2 →	+0.013	+4.736	<.001	.009	3	1
BLOOD_Leukemia	ARHGAP36 →	+0.012	+3.944	.006	.006	3	1
BLOOD_Leukemia	MBD3L2B →	+0.021	+4.384	<.001	.006	3	1
BLOOD_Leukemia	C1orf185 →	+0.059	+4.450	.002	.001	3	1
BLOOD_Leukemia	PRB1 →	+0.023	+3.551	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

RBMY1A1 by UFL1 expression — OVARY

Explore this box plot interactively →