UFD1

Across TCGA pan-cancer cohorts, UFD1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated UFD1 data layer compared with 22 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher UFD1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated UFD1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and PDAC show a favorable association.

LSCC, HNSC, and CCRCC are the cancer types where UFD1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Quartile	III,IV	0.239	0.867	.013	8	view →
HNSC	OS	Median	All	1.000	0.484	.038	6	view →
CCRCC	DFS	Median	All	0.647	0.840	.023	3	view →
PDAC	OS	Quartile	II,III,IV	0.904	0.726	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

UFD1–LSCC (DFS)

Open the LSCC breakdown →