UFD1

Across TCGA patient cohorts, UFD1 mutation is significantly associated with the RNA expression of many other genes, with 958 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UFD1-associated genes across cancer lineages are RN7SKP181, RNA5SP432, and RNU1-14P. Each is linked with UFD1 in more than 2 cancer types. Because this analysis shows association rather than direction, both UFD1-to-partner and partner-to-UFD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP181 grouped by UFD1-low versus UFD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UFD1→partner) and Y-score (partner→UFD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SKP181 →	+0.116	+2.548	<.001	.007	3	3
CESC	RNA5SP432 →	+0.299	+5.539	.001	.004	3	2
CESC	RNU1-14P →	+0.242	+5.539	<.001	.004	3	2
UCEC	RNA5SP420 →	+0.683	+2.604	<.001	<.001	3	2
UCEC	RNA5SP411 →	+1.029	+2.031	<.001	.007	3	2
BRCA	DPPA2P1 →	+0.099	+7.731	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 958 associations by consensus.

RN7SKP181 by UFD1 expression — UCEC

Explore this box plot interactively →