UEVLD

Across TCGA pan-cancer cohorts, UEVLD mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of UEVLD’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where UEVLD mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types UEVLD is over-expressed in tumor, although a few such as COAD and CCRCC show the opposite, repressed pattern.

COAD, CCRCC, and LSCC are the cancer types where UEVLD tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in UEVLD mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	II,III,IV	−0.340	<.001	11	view →
CCRCC	Male	All	−0.164	<.001	6	view →
LSCC	All	II,III,IV	−0.138	<.001	6	view →
PDAC	Female	All	+0.300	<.001	5	view →
LUAD	All	II,III,IV	+0.088	.008	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

UEVLD–COAD

Open the COAD breakdown →