UCP2

Across TCGA patient cohorts, UCP2 mutation is significantly associated with the RNA expression of many other genes, with 618 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible UCP2-associated genes across cancer lineages are MIR3648-1, OR7A8P, and RNU6-358P. Each is linked with UCP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UCP2-to-partner and partner-to-UCP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR3648-1 grouped by UCP2-low versus UCP2-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UCP2→partner) and Y-score (partner→UCP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MIR3648-1 →	+0.068	+7.057	<.001	.009	3	2
LIHC	OR7A8P →	+0.060	+6.008	<.001	.002	3	2
LUSC	RNU6-358P →	+0.664	+4.548	<.001	.009	3	2
UCEC	HMGB1P17 →	+0.195	+3.048	<.001	<.001	3	2
HNSC	OR4L1 →	+0.414	+6.339	<.001	.001	3	1
UCEC	NTAN1 →	+0.562	+3.346	.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 618 associations by consensus.

MIR3648-1 by UCP2 expression — BRCA

Explore this box plot interactively →