UCP2

Across TCGA cell cohorts, UCP2 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible UCP2-associated genes across cancer lineages are SIGLEC8, DPEP3, and FCN2. Each is linked with UCP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both UCP2-to-partner and partner-to-UCP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC8 grouped by UCP2-low versus UCP2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (UCP2→partner) and Y-score (partner→UCP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SIGLEC8 →	+0.013	+3.930	<.001	.003	3	1
LARGE_INTESTINE	DPEP3 →	+0.030	+3.793	.003	.007	3	1
LARGE_INTESTINE	FCN2 →	+0.040	+5.000	<.001	<.001	3	1
LARGE_INTESTINE	BPIFB6 →	+0.020	+4.437	<.001	.004	3	1
LARGE_INTESTINE	ADH1A →	+0.160	+3.920	<.001	.005	3	1
LARGE_INTESTINE	OR1J2 →	+0.077	+3.684	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

SIGLEC8 by UCP2 expression — LARGE_INTESTINE

Explore this box plot interactively →